Poster Presentation: Postoperative Nausea and Vomiting Prophylaxis in Women Undergoing Laparoscopic Surgery-Postoperative Nausea and Vomiting Prophylaxis in Women Undergoing Laparoscopic Surgery

Postoperative Nausea and Vomiting Prophylaxis in Women Undergoing Laparoscopic Surgery

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A retrospective study conducted by the Mayo Foundation for Medical Education and Research aimed to compare the efficacy of droperidol and haloperidol in preventing postoperative nausea and vomiting (PONV) in female patients undergoing laparoscopic surgery. Analyzing data from 1,679 patients, the study identified notable differences in PONV outcomes between the two drugs.<br /><br />The study included female patients aged 18 or older who underwent laparoscopic procedures and received either droperidol or haloperidol. Exclusion criteria included total intravenous anesthesia (TIVA), preoperative aprepitant use, current pregnancy, and regional blocks.<br /><br />Key findings indicated that patients who received haloperidol had a higher incidence of PONV (11.5%) compared to those who received droperidol (7.4%), with the administration of haloperidol increasing the odds of experiencing PONV by 61% (Odds Ratio 1.61, 95% CI 1.13 to 2.28).<br /><br />Secondary outcomes showed that patients administered haloperidol experienced higher mean pain scores (5.00 vs. 4.60 on a scale of 0-10) and required more opioids (9.07 vs. 7.66 IV MME) in the Postanesthesia Care Unit (PACU). Additionally, these patients had a longer PACU stay (109.8 vs. 95.5 minutes) compared to those who received droperidol.<br /><br />Despite the comprehensive comparison, the study acknowledged limitations, including its retrospective nature, disproportional sample sizes, and potential unmeasured confounders. The researchers emphasized the need for future prospective randomized clinical trials to confirm these findings conclusively.<br /><br />In conclusion, while haloperidol is frequently used as a substitute for droperidol due to cost and availability issues, this study suggests that droperidol is more effective in reducing the incidence of PONV and is associated with better postoperative pain and shorter PACU stays.

Keywords

PONV

droperidol

haloperidol

laparoscopic surgery

retrospective study

postoperative pain

opioid use

PACU stay

Mayo Foundation

clinical trials