This journal course explores the emerging relationship between the gut microbiome and chronic pain through the microbiome–gut–brain axis. Learners will examine how gut microbiota influence neuroinflammation, immune responses, and central sensitization, as well as the role of microbial metabolites and dysbiosis in shaping pain pathways. The course reviews current preclinical and clinical evidence linking microbiome alterations to various chronic pain conditions, including inflammatory, neuropathic, and visceral pain, and highlights the impact of factors such as opioids and gut barrier dysfunction. Emphasis is placed on enhancing CRNA understanding of these mechanisms to support more comprehensive, evidence-informed approaches to pain management.
Learning Outcomes:
1. Describe the bidirectional communication between the gut microbiome and the central nervous system via the gut-brain axis.
2. Explain the mechanisms by which gut dysbiosis contributes to neuroinflammation and central sensitization in chronic pain.
3. Identify the role of gut microbiota-derived metabolites in modulating peripheral and central pain pathways.
4. Discuss preclinical and clinical evidence linking gut microbiota composition to various chronic pain conditions.
This program has been prior approved by the American Association of Nurse Anesthesiology for 1.00 MAC Ed CE credits; Code Number 1046794; Expiration Date 4/5/2027.
The American Association of Nurse Anesthesiology designates this program as meeting the criteria for up to 1.00 CE credits in Pain Management.