The desire to limit narcotic use, coupled with a desire for efficacious pain relief with few side effects, has led researchers and providers alike to focus on the possibilities inherent in the exploitation of the endocan¬nabinoid system. In particular, fatty acid amide hydrolase (FAAH) inhibitors and monoamine glycerol lipase (MAGL) inhibitors hold great potential to become some of the next new classifications of pharmaceuticals formulated for not only pain relief, but a host of other conditions as well. This course is designed to introduce the reader to the endocannabinoid system, its components and mechanism of action, and exam¬ine how its effects are currently employed in anesthe¬sia. Results from preclinical and clinical trials will be analyzed. In addition, concerns regarding long-term effects from the activation.
Learning Outcome(s):
- Describe the endocannabinoid system, its components, and their mechanisms of action.
- Discuss past and present utilization of the endocannabinoid system for analgesia and anesthesia.
- Discuss the types of conditions being explored for treatment by pharmacological endocannabinoid manipulation.
- Examine barriers to development of drugs that enhance the endocannabinoid system.
- Discuss concerns regarding neuroplasticity of the EC system due to long-term activation.
This program has been prior approved by the American Association of Nurse Anesthesiology for 1.00 Class A CE credits; Code Number 1040716; Expiration Date 5/31/2024.